Delestrogen

Delestrogen is a prescription medication used to treat symptoms of menopause including hot flashes and vaginal dryness. It is used to treat conditions in which a woman's ovaries do not produce enough estrogen naturally (hypoestrogenism). Delestrogen is also used to help prevent osteoporosis after menopause and symptoms associated with prostate cancer. 

Delestrogen contains estradiol which is a form of the hormone estrogen. It replaces estrogen that is not naturally produced by the ovaries.

Delestrogen is available in an injectable form to be given directly into a muscle (IM).

Common side effects of Delestrogen include headache and breast pain. 

Delestrogen is a prescription medication used to treat symptoms of menopause including hot flashes and vaginal dryness. It is used to treat conditions in which a woman's ovaries do not produce enough estrogen naturally (hypoestrogenism). It is used to help prevent osteoporosis after menopause and symptoms associated with prostate cancer. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

• Par Pharmaceutical , Inc

Serious side effects have been reported with Delestrogen. See the “Delestrogen” section.

Common side effects of Delestrogen include the following:

• Headache
• Breast pain
• Irregular vaginal bleeding or spotting
• Stomach/abdominal cramps, bloating
• Nausea and vomiting
• Hair loss

This is not a complete list of Delestrogen side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• Amiodarone (Cordarone, Pacerone)
• Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
• Aprepitant (Emend)
• Carbamazepine (Carbatrol, Epitol, Tegretol)
• Cimetidine (Tagamet)
• Clarithromycin (Biaxin)
• Cyclosporine (Neoral, Sandimmune)
• Dexamethasone (Decadron, Dexpak)
• Diltiazem (Cardizem, Dilacor, Tiazac, others)
• Erythromycin (E.E.S, Erythrocin)
• Fluoxetine (Prozac, Sarafem)
• Fluvoxamine (Luvox)
• Griseofulvin (Fulvicin, Grifulvin, Gris-PEG)
• Lovastatin (Altocor, Mevacor)
• Medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase)
• Medications for thyroid disease
• Nefazodone
• Other medications that contain estrogen
• Phenobarbital
• Phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin)
• Rifampin 
• Sertraline (Zoloft)
• Troleandomycin (TAO)
• Verapamil (Calan, Covera, Isoptin, Verelan)
• Zafirlukast (Accolate)
• St. John's Wort

This is not a complete list of Delestrogen drug interactions. Ask your doctor or pharmacist for more information.

Serious side effects have been reported with Delestrogen including the following:

• bulging eyes
• yellowing of the skin or eyes
• itching
• loss of appetite
• fever
• joint pain
• stomach tenderness, pain, or swelling
• movements that are difficult to control
• hives
• rash or blisters on the skin
• swelling, of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
• hoarseness
• wheezing
• difficulty breathing or swallowing

Do not take Delestrogen if you:

• are allergic to Delestrogen or to any of its ingredients
• have abnormal vaginal bleeding
• have a known or suspected history of breast cancer
• have a known or suspected estrogen-dependent cancer
• currently have or have a history of blood clots
• have liver disease
• had a stroke or heart attack in the past year
• are pregnant or possibly pregnant

Grapefruit and grapefruit juice may interact with Delestrogen and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Before taking Delestrogen, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

• are allergic to Delestrogen or to any of its ingredients
• currently have or have a history of blood clots
• currently have or have had certain cancers
• have unusual vaginal bleeding.
• had a stroke or heart attack in the past year
• you have certain conditions, such as asthma (wheezing), epilepsy (seizures), migraine, endometriosis, lupus, problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.
• about all the medicines you take. This includes prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how Delestrogen works. Delestrogen may also affect how your other medicines work.
• if you are going to have surgery or will be on bed rest
• are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are pregnant or plan to become pregnant.

Delestrogen should not be used during pregnancy. There appears to be little or no increased risk of birth defects in children born to women who inadvertently used estrogens during early pregnancy. Talk to your doctor right away if you become pregnant while taking Delestrogen.

Tell your doctor if you are breastfeeding or plan to breastfeed.

Estrogen has been detected in human breast milk. Estrogen can decrease the quality or quantity of breast milk. Caution should be taken if Delestrogen is given to a nursing mother. 

Delestrogen is available in an injectable form to be given directly into a muscle (IM).

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication

For treatment of moderate to severe vasomotor symptoms, vulvar and vaginal atrophy associated with the menopause, your doctor will prescribe the lowest dose and regimen that will control symptoms should be chosen. Your doctor will stop your as promptly as possible. The usual dosage is 10 to 20 mg Delestrogen every four weeks. Attempts to discontinue or taper medication should be made at 3-month to 6-month intervals.

For treatment of female hypoestrogenism due to hypogonadism, castration, or primary ovarian failure. The usual dosage is 10 to 20 mg Delestrogen every four weeks.

For treatment of advanced androgen-dependent carcinoma of the prostate, for palliation only. The usual dosage is 30 mg or more administered every one or two weeks.

If Delestrogen is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

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